Dusseldorf, Germany, March 5, 2026 – (“Priavoid”) today declared that it will present promising preliminary safety data from the ongoing Phase 2 trial (PRImus-AD, ) evaluating its leading candidate PRI-002 in Alzheimer’s disease (AD), as well as preclinical proof-of-concept data for its candidate PRI-101 in alpha-synucleinopathy models such as Parkinson’s disease (PD) at the upcoming AD/PD™ 2026 International Conference, which will be held from March 17-21, 2026 in Copenhagen, Denmark. Both candidates are based on Priavoid’s proprietary development platform and represent a new class of orally administrable all-d-peptide therapeutics designed to untangle neurotoxic oligomer species to impede and reverse disease-specific protein aggregation in neurodegenerative disorders.
Initial Phase 2 safety data for PRI-002, which targets amyloid-beta (Aβ) oligomers, will be outlined in an oral presentation by Priavoid’s Chief Science Officer, Prof. Dr. Dieter Willbold. The results show a favorable safety and tolerability profile, particularly regarding Amyloid-Related Imaging Abnormalities (ARIA). Following review of relevant safety data, the Drug Safety and Monitoring Board (DSMB) recommended continuing the trial without further ARIA monitoring.
The preclinical proof-of-concept data for PRI-101, a candidate intended to target alpha-synuclein (α-syn) aggregates, will be shared as a poster presentation and include encouraging efficacy data in several in vitro and in vivo PD models.
Priavoid will also present additional posters, including updates from its discovery-stage programs aimed at tackling tauopathies and amyotrophic lateral sclerosis (ALS).
Details of the Talk and Poster Sessions:
Oral Presentation:
Abstract Title: The Abeta Oligomer Disassembling Compound PRI-002 Does Not Induce ARIA in an Ongoing Phase 2 Trial (ID 2426)
Presenting author: Prof. Dr. Dieter Willbold, Priavoid GmbH
Session: 4760 – The App Pathway: From Hidden Fragments to Therapeutic Targets in AD
Date & Time: March 17, 2026, at 3:30 pm CET / 9:30 am EST
Poster:
Abstract Title: #514: Disassembly of α-Synuclein Aggregates by the All-d-Peptide PRI-101: Preclinical Efficacy In Vitro and In Vivo
Presenting author: Dr. Marc Sevenich, Priavoid GmbH
Date & Time: March 19, 2026, 1:50 pm CET until March 21, 2026, 5 pm CET
Poster board number: SHIFT 02-152
Details for additional poster presentations at AD/PD 2026 can be found .
The PRImus-AD trial is funded by PRInnovation GmbH, an affiliate to The Federal Agency for Breakthrough Innovation – .
About Priavoid
Priavoid’s new class of orally available all-d-peptide therapeutics untangles neurotoxic oligomer species to impede and reverse disease-specific protein aggregation in neurodegenerative disorders. We aim to establish clinical proof-of-concept through our lead program, PRI-002, which will conclude a Phase 2 trial in Alzheimer’s disease in 2026. Priavoid has constructed a focused pipeline of detangler compounds that are non-immunogenic and reach their oligomer targets in the brain and within the affected cells. Our objective is to develop disease-modifying therapies that address the underlying biology of neurodegeneration and deliver significant clinical benefit to patients.
Contacts:
Priavoid GmbH
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Anja Heuer and Marie Weickert, PhD
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